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Article

HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.

RNA biology - 1 Apr 2020

Zhao Quan, Li Chen, Yu Meng, Sun Yimin, Wang Jian, Ma Lixiang, Sun Xiaoli, Lu Boxun

Abstract excerpt

Huntington's Disease (HD) is a monogenetic neurodegenerative disorder mainly caused by the cytotoxicity of the mutant HTT protein (mHTT) encoded by the mutant HTT gene. Lowering HTT mRNA has been extensively studied as a potential therapeutic strategy, but how its level is regulated endogenously has been unclear. Here we report that the RNA-binding protein (RBP) HuR interacts with and stabilizes HTT mRNA in an...

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Identifiers

PMID: 31928144
DOI: 10.1080/15476286.2020.1712894
PMCID: PMC7237150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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