Article
Non-motor Symptoms in Parkinson's Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction.
Journal of molecular neuroscience : MN - 1 Feb 2020
Song Jie, Shen Bo, Yang Yu-Jie, Liu Feng-Tao, Zhao Jue, Tang Yi-Lin, Chen Chen, Ding Zheng-Tong, An Yu, Wu Jian-Jun, Sun Yi-Min, Wang Jian
Abstract excerpt
The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson's disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients (N = 261) underwent targeted sequencing of Parkinson's disease (PD) related genes. Among them, 53 cases carried homozygous or compound heterozygous Parkin mutations (Parkin group) while 208 did not...
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