Article
Disease Progression in Patients with Parkin-Related Parkinson's Disease in a Longitudinal Cohort.
Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2021
Sun Yi-Min, Yu Hui-Ling, Zhou Xin-Yue, Xiong Wei-Xi, Luo Su-Shan, Chen Chen, Liu Feng-Tao, Zhao Jue, Tang Yi-Lin, Liang Xiao-Niu, Yang Yu-Jie, Shen Bo, Shen Yan, Yu Wen-Bo, Ding Zheng-Tong, An Yu, Wu Jian-Jun, Wang Jian
Abstract excerpt
BACKGROUND: There was a paucity of follow-up studies in the disease progression of early-onset PD patients with Parkin mutations (Parkin-EOPD). Here we conducted a longitudinal study to investigate the progression of motor and cognitive features of Parkin-EOPD patients. METHODS: Genetic analysis was performed via target sequencing and multiplex ligation-dependent probe amplification. Thirty patients carrying...
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