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Article

ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA.

Bioinformatics (Oxford, England) - 1 May 2020

Casiraghi Nicola, Orlando Francesco, Ciani Yari, Xiang Jenny, Sboner Andrea, Elemento Olivier, Attard Gerhardt, Beltran Himisha, Demichelis Francesca, Romanel Alessandro

Abstract excerpt

MOTIVATION: The use of liquid biopsies for cancer patients enables the non-invasive tracking of treatment response and tumor dynamics through single or serial blood drawn tests. Next-generation sequencing assays allow for the simultaneous interrogation of extended sets of somatic single-nucleotide variants (SNVs) in circulating cell-free DNA (cfDNA), a mixture of DNA molecules originating both from normal and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31922552
DOI: 10.1093/bioinformatics/btaa016
PMCID: PMC7203757

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