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Article

Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia.

The Journal of clinical investigation - 1 Sept 2017

Lall Deepti, Baloh Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss of motor neurons and shows clinical, pathological, and genetic overlap with frontotemporal dementia (FTD). Activated microglia are a universal feature of ALS/FTD pathology; however, their role in disease pathogenesis remains incompletely understood. The recent discovery that ORF 72 on chromosome 9 (C9orf72), the gene most...

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Identifiers

PMID: 28737506
DOI: 10.1172/JCI90607
PMCID: PMC5669558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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