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Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia

13 Aug 2021

Abstract excerpt

PURPOSE OF REVIEW: An intronic G4C2 expansion mutation in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). Although there are currently no treatments for this insidious, fatal disease, intense research has led to promising therapeutic strategies, which will be discussed here. RECENT FINDINGS: Therapeutic strategies for C9-ALS/FTD have primarily...

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PMID: 34392299
DOI: 10.1097/wco.0000000000000984

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