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Article

Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny.

Molecular neurobiology - 1 Apr 2020

Patel Nirav J, Hogan Kirk J, Rizk Elias, Stewart Krista, Madrid Andy, Vadakkadath Meethal Sivan, Alisch Reid, Borth Laura, Papale Ligia A, Ondoma Solomon, Gorges Logan R, Weber Kara, Lake Wendell, Bauer Andrew, Hariharan Nithya, Kuehn Thomas, Cook Thomas, Keles Sunduz, Newton Michael A, Iskandar Bermans J

Abstract excerpt

Folate supplementation in F0 mating rodents increases regeneration of injured spinal axons in vivo in 4 or more generations of progeny (F1-F4) in the absence of interval folate administration to the progeny. Transmission of the enhanced regeneration phenotype to untreated progeny parallels axonal growth in neuron culture after in vivo folate administration to the F0 ancestors alone, in correlation with...

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Identifiers

PMID: 31919777
DOI: 10.1007/s12035-019-01812-5
PMCID: PMC7125003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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