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Article

Precision prophylaxis: Identifying the optimal timing for risk-reducing salpingo-oophorectomy based on type of BRCA1 and BRCA2 cluster region mutations.

Gynecologic oncology - 1 Feb 2020

Solsky Ian, Chen Jinbo, Rebbeck Timothy R

Abstract excerpt

OBJECTIVES: Current risk-reducing salpingo-oophorectomy (RRSO) guidelines for individuals with BRCA1/2 mutations do not account for risk variability due to BRCA1/2 cluster region mutations that are associated with varying risks for the development of breast and ovarian cancer. We assessed whether current recommendations are appropriate for individual patients considering mutation-specific risks. METHODS: Using a...

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Identifiers

PMID: 31918993
DOI: 10.1016/j.ygyno.2019.11.036
PMCID: PMC9148810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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