Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity.

Structure (London, England : 1993) - 3 Mar 2020

Tayeb-Fligelman Einav, Salinas Nir, Tabachnikov Orly, Landau Meytal

Abstract excerpt

The phenol-soluble modulin (PSM) peptide family, secreted by Staphylococcus aureus, performs various virulence activities, some mediated by the formation of amyloid fibrils of diverse architectures. Specifically, PSMα1 and PSMα4 structure the S. aureus biofilm by assembling into robust cross-β amyloid fibrils. PSMα3, the most cytotoxic member of the family, assembles into cross-α fibrils in which α helices stack...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Bacterial Toxins
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Models, Molecular

Share to Protein Aggregates

Share to Staphylococcus aureus

Share to T-Lymphocytes

Source

Identifiers

PMID: 31918959
DOI: 10.1016/j.str.2019.12.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity.PMID 31918959Read ↗

Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptidesSemantic proximity Read ↗

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibrilSemantic proximity Read ↗

Structure of biofilm-forming functional amyloid PSMα1 from Staphylococcus aureusSemantic proximity Read ↗

Serum modulates the aggregation - toxicity landscape of the staphylococcal toxin PSMα3Semantic proximity Read ↗

Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream InfectionSemantic proximity Read ↗

Phenol-soluble modulins – critical determinants of staphylococcal virulenceSemantic proximity Read ↗

Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.Semantic proximity Read ↗

Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structureSemantic proximity Read ↗

The psm α Locus Regulates Production of Staphylococcus aureus Alpha-Toxin during InfectionSemantic proximity Read ↗

Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from <i>Staphylococcus aureus</i>Semantic proximity Read ↗

PSMε controls skin commensal CD8 <sup>+</sup> T cell activationSemantic proximity Read ↗

Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive AutoimmunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.