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Article

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

23 Feb 2017

Abstract excerpt

What's in a fold? Bacterially secreted peptides known as PSMs (phenol-soluble modulins) stimulate inflammatory responses, lyse human cells, and contribute to biofilm structuring. PSMα3 is a virulent 22-residue amyloid peptide secreted by Staphylococcus aureus. Tayeb-Fligelman et al. present a high-resolution structure encompassing the full length of the amyloid's sequence. This structure reveals an unexpected...

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PMID: 28232575
DOI: 10.1126/science.aaf4901

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