Article

Serum modulates the aggregation - toxicity landscape of the staphylococcal toxin PSMα3

2026-02-22

Abstract excerpt

The pathogenicity of Staphylococcus aureus relies on the secretion of various toxins, including phenol-soluble modulins α3 (PSMα3), which play key roles in invasion and infection through its cytolytic activities. Recent controversies have focused on whether PSMα3 propensity to self-assemble into unique amyloid-like cross-α structures would underlie its high cytotoxicity. Here, by integrating Thioflavin T fluoresc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 683d3d1d-1369-59bf-b1c2-87785e9d09ee
DOI: 10.64898/2026.02.22.707246

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serum modulates the aggregation - toxicity landscape of the staphylococcal toxin PSMα3DOI 10.64898/2026.02.22.707246Read

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibrilSemantic proximity Read

Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity.Semantic proximity Read

Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptidesSemantic proximity Read

Structure of biofilm-forming functional amyloid PSMα1 from Staphylococcus aureusSemantic proximity Read

Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structureSemantic proximity Read

Phenol-soluble modulins – critical determinants of staphylococcal virulenceSemantic proximity Read

The Role of Functional Amyloids in Bacterial VirulenceSemantic proximity Read

Emerging Roles of Functional Bacterial Amyloids in Gene Regulation, Toxicity, and ImmunomodulationSemantic proximity Read

Staphylococcus aureus α-Toxin: Nearly a Century of IntrigueSemantic proximity Read

Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream InfectionSemantic proximity Read

Exploiting amyloid: how and why bacteria use cross-β fibrilsSemantic proximity Read

Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.Semantic proximity Read