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The psm α Locus Regulates Production of Staphylococcus aureus Alpha-Toxin during Infection

28 May 2014

Abstract excerpt

Staphylococcus aureus is a leading cause of human bacterial infection, causing a wide spectrum of disease ranging from skin and soft tissue infections to life-threatening pneumonia and sepsis. S. aureus toxins play an essential role in disease pathogenesis, contributing to both immunomodulation and host tissue injury. Prominent among these toxins are the membrane-active pore-forming cytolysin alpha-toxin (Hla)...

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PMID: 24866799
DOI: 10.1128/iai.00089-14

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