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Article

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

8 Aug 2018

Abstract excerpt

Human papillomavirus type 16 (HPV16) and other oncoviruses have been shown to block innate immune responses and to persist in the host. However, to avoid viral persistence, the immune response attempts to clear the infection. IL-1β is a powerful cytokine produced when viral motifs are sensed by innate receptors that are members of the inflammasome family. Whether oncoviruses such as HPV16 can activate the...

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PMID: 30089163
DOI: 10.1371/journal.ppat.1007158

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