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The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

1 Jan 2020

Abstract excerpt

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented, negative-sense RNA viral (sNSV) pathogens with potential global health impact. Here, we characterize the amino-terminal cap-snatching endonuclease domain of SFTSV polymerase...

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Identifiers

PMID: 31914382
DOI: 10.1016/j.celrep.2019.12.020

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