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Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect

21 Sept 2023

Abstract excerpt

ABSTRACT The cap-snatching mechanism mediated by cap-dependent endonuclease, which is common among the negative-stranded, segmented RNA viruses in Orthomyxoviridae , Bunyaviridae, and Arenaviridae , is crucial for viral transcription and replication and is thus an attractive target for antiviral drug development. Herein, tanshinone I and its analog tanshinone IIA were identified as candidate compounds with...

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PMID: 37732786
DOI: 10.1128/jvi.00796-23

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