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Structure and function of the Toscana virus cap-snatching endonuclease

2 Oct 2019

Abstract excerpt

Toscana virus (TOSV) is an arthropod-borne human pathogen responsible for seasonal outbreaks of fever and meningoencephalitis in the Mediterranean basin. TOSV is a segmented negative-strand RNA virus (sNSV) that belongs to the genus phlebovirus (family Phenuiviridae, order Bunyavirales), encompassing other important human pathogens such as Rift Valley fever virus (RVFV). Here, we carried out a structural and...

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PMID: 31584100
DOI: 10.1093/nar/gkz838

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