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Article

Pyruvate kinase revisited: the activating effect of K+.

The Journal of biological chemistry - 11 Nov 2005

Oria-Hernández Jesús, Cabrera Nallely, Pérez-Montfort Ruy, Ramírez-Silva Leticia

Abstract excerpt

For more than 50 years, it has been known that K(+) is an essential activator of pyruvate kinase (Kachmar, J. F., and Boyer, P. D. (1953) J. Biol. Chem. 200, 669-683). However, the role of K(+) in the catalysis by pyruvate kinase has not been totally understood. Previous studies without K(+) showed that the affinity of ADP-Mg(2+) depends on the concentration of phosphoenolpyruvate, although the kinetics of the...

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PMID: 16147999
DOI: 10.1074/jbc.M508490200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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