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Article

Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase.

PloS one - 23 Nov 2010

Usenik Aleksandra, Legiša Matic

Abstract excerpt

As an important part of metabolism, metabolic flux through the glycolytic pathway is tightly regulated. The most complex control is exerted on 6-phosphofructo-1-kinase (PFK1) level; this control overrules the regulatory role of other allosteric enzymes. Among other effectors, citrate has been reported to play a vital role in the suppression of this enzyme's activity. In eukaryotes, amino acid residues forming the...

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Identifiers

PMID: 21124851
DOI: 10.1371/journal.pone.0015447
PMCID: PMC2990764

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Source receipt: pubmed, retrieved 7 Sept 2026.

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