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Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer.

Hereditas - 1 Jan 2020

Wu Yu, Zhang Huanhuan, Weng Xiaoling, Wang Honglian, Zhou Qinghua, Wu Ying, Shen Yi, Hu Zhen

Abstract excerpt

BACKGROUND: Breast cancer is a one of the malignant carcinomas partially caused by genetic risk factors. Germline BRCA1 gene mutations are reportedly associated with breast cancers. Identification of BRCA1 mutations greatly improves the preventive strategies and management of breast cancer. The aim of our study was to investigate the frequency of the deleterious BRCA1: p.Ile1845fs variant in breast carcinomas, as...

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Identifiers

PMID: 31908633
DOI: 10.1186/s41065-019-0115-7
PMCID: PMC6937991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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