Article
pVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens.
Cancer immunology research - 1 Mar 2020
Hundal Jasreet, Kiwala Susanna, McMichael Joshua, Miller Christopher A, Xia Huiming, Wollam Alexander T, Liu Connor J, Zhao Sidi, Feng Yang-Yang, Graubert Aaron P, Wollam Amber Z, Neichin Jonas, Neveau Megan, Walker Jason, Gillanders William E, Mardis Elaine R, Griffith Obi L, Griffith Malachi
Abstract excerpt
Identification of neoantigens is a critical step in predicting response to checkpoint blockade therapy and design of personalized cancer vaccines. This is a cross-disciplinary challenge, involving genomics, proteomics, immunology, and computational approaches. We have built a computational framework called pVACtools that, when paired with a well-established genomics pipeline, produces an end-to-end solution for...
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