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Article

pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.

Genome medicine - 29 Jan 2016

Hundal Jasreet, Carreno Beatriz M, Petti Allegra A, Linette Gerald P, Griffith Obi L, Mardis Elaine R, Griffith Malachi

Abstract excerpt

Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tumor-specific mutant peptides (neoantigens) can elicit anti-tumor T cell immunity are needed to improve predictions of checkpoint therapy response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26825632
DOI: 10.1186/s13073-016-0264-5
PMCID: PMC4733280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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