Natural variants of apolipoprotein A1 L99P and R173P exhibited a high degree of amyloid fibril formation: Implications for high-density lipoprotein functions and disease pathogenesis.

Abstract excerpt

Apolipoprotein A1 (ApoA1), the primary protein component of high-density lipoprotein (HDL), plays a crucial role in cholesterol transport and cardiovascular protection. However, specific mutations in ApoA1 are associated with hereditary amyloidosis, a condition marked by protein misfolding and deposition of amyloid fibrils in various tissues. This study aimed to experimentally characterize the structural and...

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