Article
Amyloid fibril formation in gelsolin-derived amyloidosis. Definition of the amyloidogenic region and evidence of accelerated amyloid formation of mutant Asn-187 and Tyr-187 gelsolin peptides.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 1994
Maury C P, Nurmiaho-Lassila E L, Rossi H
Abstract excerpt
BACKGROUND: We have recently shown that the actin-modulating cytoskeletal and plasma protein gelsolin is involved in the pathogenesis of familial amyloidosis of Finnish type. To define the amyloidogenic region(s) in gelsolin and clarify the mechanisms involved in amyloid formation, we tested the amyloidogenicity of synthetic gelsolin peptide analogues. EXPERIMENTAL DESIGN: The in vitro amyloid fibril formation...
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