Article
Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2020
Mishra Manoj K, Liang Eugene Y, Geurts Aron M, Auer Paul W L, Liu Pengyuan, Rao Sridhar, Greene Andrew S, Liang Mingyu, Liu Yong
Abstract excerpt
The objective of the current study is to use comparative and functional genomic analysis to help to understand the biological mechanism mediating the effect of single nucleotide polymorphisms (SNPs) on blood pressure. We mapped 26 585 SNPs that are in linkage disequilibrium with 1071 human blood pressure-associated sentinel SNPs to 9447 syntenic regions in the mouse genome. Approximately 21.8% of the 1071 linkage...
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