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Article

Molecular systems, human noncoding sequence variants, and blood pressure.

Physiological reviews - 1 Apr 2026

Qiu Qiongzi, Liang Mingyu

Abstract excerpt

The human genome harbors millions of noncoding sequence variants. Genome-wide association studies (GWAS) have identified thousands of robust associations linking noncoding variants to human physiological traits and complex diseases. Integrative approaches, including expression quantitative trait locus mapping, epigenomic profiling, and precise genome editing in trait-relevant cell types, enable the identification...

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PMID: 41616807
DOI: 10.1152/physrev.00029.2025
PMCID: PMC12965744

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