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Article

Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma

1 Jan 2016

Abstract excerpt

AIM: To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS: ) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting (MS-HRM) analysis. mRNA expression...

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PMID: 28058013
DOI: 10.3748/wjg.v22.i47.10325

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