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Article

Immunohistochemical detection of senescence markers in human sarcomas.

Pathology, research and practice - 1 Feb 2020

Giatromanolaki Alexandra, Kouroupi Maria, Balaska Konstantina, Koukourakis Michael I

Abstract excerpt

INTRODUCTION: Senescent cells in tumors are not inert cells but exert bystander effects by developing secretory phenotypes affecting the extracellular matrix and interfering the biological behavior of adjacent tumor cells. MATERIALS AND METHODS: We assessed putative senescent cell content in a series of human sarcomas, using in parallel markers related to cell proliferation (Ki67), DNA damage (γH2Ax), lipofuscin...

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Source

Identifiers

PMID: 31899047
DOI: 10.1016/j.prp.2019.152800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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