Article
Schwannomas, benign tumors with a senescent phenotype.
Histology and histopathology - 1 Jun 2014
Simonetti S, Serrano C, Hernández-Losa J, Bagué S, Orellana R, Valverde C, Lleonart M E, Aizpurua M, Carles J, Ramón y Cajal S, Romagosa C
Abstract excerpt
BACKGROUND: Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence...
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