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Article

Complementing mutations in core binding factor leukemias: from mouse models to clinical applications.

Oncogene - 2 Oct 2008

Müller A M S, Duque J, Shizuru J A, Lübbert M

Abstract excerpt

A great proportion of acute myeloid leukemias (AMLs) display cytogenetic abnormalities including chromosomal aberrations and/or submicroscopic mutations. These abnormalities significantly influence the prognosis of the disease. Hence, a thorough genetic work-up is an essential constituent of standard diagnostic procedures. Core binding factor (CBF) leukemias denote AMLs with chromosomal aberrations disrupting one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 18604246
DOI: 10.1038/onc.2008.196

Genes

KIT
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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