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Article

The growing role of epigenetics in childhood cancers

31 Dec 2019

Abstract excerpt

PURPOSE OF REVIEW: Altered epigenetics is central to oncogenesis in many pediatric cancers. Aberrant epigenetic states are induced by mutations in histones or epigenetic regulatory genes, aberrant expression of genes regulating chromatin complexes, altered DNA methylation patterns, or dysregulated expression of noncoding RNAs. Developmental contexts of dysregulated epigenetic states are equally important for...

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PMID: 31895160
DOI: 10.1097/mop.0000000000000867

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