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Article

Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors

30 Jul 2014

Abstract excerpt

A remarkably large number of "epigenetic regulators" have been recently identified to be altered in cancers and a rapidly expanding body of literature points to "epigenetic addiction" (an aberrant epigenetic state to which a tumor is addicted) as a new previously unsuspected mechanism of oncogenesis. Although mutations are also found in canonical signaling pathway genes, we and others identified...

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PMID: 25077668
DOI: 10.1007/s00401-014-1325-8

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