Article

Learning High-Order Interactions for Polygenic Risk Prediction

2022-04-22

Abstract excerpt

Within the framework of precision medicine, the stratification of individual genetic susceptibility based on inherited DNA variation has paramount relevance. However, one of the most relevant pitfalls of traditional Polygenic Risk Scores (PRS) approaches is their inability to model complex high-order non-linear SNP-SNP interactions and their effect on the phenotype (e.g. epistasis). Indeed, they incur in a computa...

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Literature Corpus work: 7a7b1d6a-8300-51b3-a4a9-c5c6a7bb9186
DOI: 10.1101/2022.04.22.489134

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