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Article

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

PloS one - 1 Jan 2019

Park Dongju, Shakya Reena, Koivisto Christopher, Pitarresi Jason R, Szabolcs Matthias, Kladney Raleigh, Hadjis Ashley, Mace Thomas A, Ludwig Thomas

Abstract excerpt

Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of genome integrity following DNA double-strand breaks. To determine if the role of PALB2 as a linker between BRCA1 and BRCA2 is critical for BRCA1/2-mediated tumor...

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Identifiers

PMID: 31877165
DOI: 10.1371/journal.pone.0226714
PMCID: PMC6932818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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