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Article

BRCA-mutant pancreatic ductal adenocarcinoma.

British journal of cancer - 1 Nov 2021

Lai Eleonora, Ziranu Pina, Spanu Dario, Dubois Marco, Pretta Andrea, Tolu Simona, Camera Silvia, Liscia Nicole, Mariani Stefano, Persano Mara, Migliari Marco, Donisi Clelia, Demurtas Laura, Pusceddu Valeria, Puzzoni Marco, Scartozzi Mario

Abstract excerpt

Despite continued research, pancreatic ductal adenocarcinoma (PDAC) remains one of the main causes of cancer death. Interest is growing in the role of the tumour suppressors breast cancer 1 (BRCA1) and BRCA2-typically associated with breast and ovarian cancer-in the pathogenesis of PDAC. Indeed, both germline and sporadic mutations in BRCA1/2 have been found to play a role in the development of PDAC. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34262146
DOI: 10.1038/s41416-021-01469-9
PMCID: PMC8575931

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