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Article

Neuromuscular junction transmission failure is a late phenotype in aging mice.

Neurobiology of aging - 1 Feb 2020

Chugh Deepti, Iyer Chitra C, Wang Xueyong, Bobbili Prameela, Rich Mark M, Arnold W David

Abstract excerpt

Neurodegeneration has increasingly been considered an important factor in the pathogenesis of sarcopenia or age-related loss of muscle mass and strength. Experiments were designed to investigate the fidelity of neuromuscular junction (NMJ) transmission across the lifespan in hindlimb muscles of male and female C57BL/6J mice (at 12, 20, 24, 27, and 29 months of age). Single-fiber electromyography recordings...

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Source

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Identifiers

PMID: 31866157
DOI: 10.1016/j.neurobiolaging.2019.10.022
PMCID: PMC6995686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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