Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm

Abstract excerpt

As mammals age, their neuromuscular junctions (NMJs) gradually change their form, acquiring an increasingly fragmented appearance consisting of numerous isolated regions of synaptic differentiation. It has been suggested that this remodelling is associated with impairment of neuromuscular transmission, and that this contributes to age-related muscle weakness in mammals, including humans. The underlying...

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