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Article

HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation

20 Dec 2019

Abstract excerpt

Human telomerase RNA component hTERC comprises multiple motifs that contribute to hTERC biogenesis, holoenzyme activity, and enzyme recruitment to telomeres. hTERC contains several guanine tracts (G-tracts) at its 5'-end, but its associated proteins and potential roles in telomerase function are still poorly understood. The heterogeneous nuclear ribonucleoproteins F, H1, and H2 (hnRNP F/H) are splicing factors...

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Share to RNA regulation and disease
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Share to Telomeres, Telomerase, and Senescence

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PMID: 31863069
DOI: 10.1038/s41418-019-0483-6

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