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Article

TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance

14 Oct 2018

Abstract excerpt

In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR. Poly(A)-specific ribonuclease (PARN) is known to trim hTR precursors by removing poly(A) tails. However, the precise mechanism of hTR 3' maturation remains largely unknown. Target of Egr1 (TOE1) is an Asp-Glu-Asp-Asp (DEDD) domain containing deadenylase that is mutated in the...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30371886
DOI: 10.1093/nar/gky1019

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TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenancePMID 30371886Read ↗

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Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerizationSemantic proximity Read ↗

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