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Article

High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2020

Hühns Maja, Nürnberg Sylvia, Kandashwamy Krishna Kumar, Maletzki Claudia, Bauer Peter, Prall Friedrich

Abstract excerpt

Hypermutator-type colorectal carcinomas are microsatellite-stable and have point mutations of the exonuclease domain of the DNA polymerase ε or δ genes (POLE and POLD1, respectively), and an ultrahigh tumor mutational burden (TMB). These tumors may be associated with enhanced antitumor immunity and preferentially afflict younger patients, but this notion awaits validation by accrual of further cases for detailed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Poly-ADP-Ribose Binding Proteins

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 31857678
DOI: 10.1038/s41379-019-0430-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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