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Article

Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.

Scientific reports - 19 Dec 2019

Kim Yun, Yoon Seonghae, Choi Yewon, Yoon Seo Hyun, Cho Joo-Youn, Jang In-Jin, Yu Kyung-Sang, Chung Jae-Yong

Abstract excerpt

A lack of information regarding whether genetic polymorphisms of SLCO1B1 and ABCG2 affect the pharmacokinetics (PKs)/pharmacodynamics (PDs) of rosuvastatin in elderly subjects prevents optimal individualized pharmacotherapy of rosuvastatin in clinical settings. This study aimed to investigate the effect of age and genetic polymorphisms and possible differences in genetic effects on the PKs/PDs of rosuvastatin...

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Identifiers

PMID: 31857620
DOI: 10.1038/s41598-019-55562-4
PMCID: PMC6923423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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