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Article

Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States.

European journal of clinical pharmacology - 1 Mar 2015

Birmingham Bruce K, Bujac Sarah R, Elsby Robert, Azumaya Connie T, Zalikowski Julie, Chen Yusong, Kim Kenneth, Ambrose Helen J

Abstract excerpt

PURPOSE: Systemic exposure to rosuvastatin in Asian subjects living in Japan or Singapore is approximately twice that observed in Caucasian subjects in Western countries or in Singapore. This study was conducted to determine whether pharmacokinetic differences exist among the most populous Asian subgroups and Caucasian subjects in the USA. METHOD: Rosuvastatin pharmacokinetics was studied in Chinese, Filipino,...

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PMID: 25630984
DOI: 10.1007/s00228-014-1800-0

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ABCG2

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