Article
Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment.
Clinical pharmacology and therapeutics - 1 Oct 2005
Lee Edmund, Ryan Stephen, Birmingham Bruce, Zalikowski Julie, March Ruth, Ambrose Helen, Moore Rachael, Lee Caroline, Chen Yusong, Schneck Dennis
Abstract excerpt
BACKGROUND: Systemic exposure to rosuvastatin had been observed to be approximately 2-fold higher in Japanese subjects living in Japan compared with white subjects in Western Europe or the United States. The organic anion transporting polypeptide 1B1 contributes to the hepatic uptake of rosuvasta...
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