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Article

Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

Clinical pharmacology and therapeutics - 1 Feb 2008

Choi J H, Lee M G, Cho J-Y, Lee J-E, Kim K H, Park K

Abstract excerpt

This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for...

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PMID: 17568401
DOI: 10.1038/sj.clpt.6100267

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