Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health

9 May 2025

Abstract excerpt

Male-factor infertility accounts for nearly half of all infertility cases, and mounting evidence points to oxidative stress as a pivotal driver of sperm dysfunction, genetic instability, and epigenetic dysregulation. In particular, the oxidative DNA lesion 8-hydroxy-2'-deoxyguanosine (8-OHdG) has emerged as a central mediator at the interface of DNA damage and epigenetic regulation. We discuss how this lesion can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40427452
DOI: 10.3390/antiox14050570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational HealthPMID 40427452Read ↗

Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring HealthSemantic proximity Read ↗

OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Sperm telomeres, oxidative stress, and infertilitySemantic proximity Read ↗

Redox Regulation of Human Sperm Function: From the Physiological Control of Sperm Capacitation to the Etiology of Infertility and DNA Damage in the Germ LineSemantic proximity Read ↗

Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunctionSemantic proximity Read ↗

The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility-A Unifying Hypothesis?Semantic proximity Read ↗

Should we be measuring DNA damage in human spermatozoa? New light on an old questionSemantic proximity Read ↗

Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoaSemantic proximity Read ↗

Oxidative stress Major executioner in disease pathology role in sperm DNA damage and preventive strategiesSemantic proximity Read ↗

Role of oxidative stress in male infertility: An updated reviewSemantic proximity Read ↗

Reactive oxygen species impact on sperm DNA and its role in male infertilitySemantic proximity Read ↗

Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future PerspectivesSemantic proximity Read ↗

Crosstalk Between Oxidative Stress and Epigenetics: Unveiling New Biomarkers in Human InfertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.