Article
Epistasis between phenylethanolamine N-methyltransferase and β2-adrenergic receptor influences extracellular epinephrine level and associates with the susceptibility to allergic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2020
Sio Yang Yie, Matta Sri Anusha, Ng Yu Ting, Chew Fook Tim
Abstract excerpt
BACKGROUND: Reduced extracellular epinephrine level often associates with asthma-related symptoms; however, the correlation between asthma and genetic variants in genes participating in the epinephrine signalling pathway remains unclear. OBJECTIVE: To characterize the functions of single nucleotide polymorphisms (SNPs) in phenylethanolamine N-methyltransferase (PNMT) and β2-adrenergic receptor (ADRB2), and to...
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