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Article

Functional variants in the chromosome 4q21 locus contribute to allergic rhinitis risk by modulating the expression of N-acylethanolamine acid amidase.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jan 2022

Sio Yang Yie, Shi Ping, Say Yee-How, Chew Fook Tim

Abstract excerpt

BACKGROUND: Previous haplotype-based association studies identified chromosome 4q21 as an allergic rhinitis (AR) susceptibility locus; however, the functional role of 4q21 single nucleotide polymorphisms (SNPs) on AR risk remains unclear. OBJECTIVE: To investigate the functional effect of 4q21 SNPs on AR risk by conducting cohort-based functional genomics and genetic association analyses. METHODS: The...

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PMID: 33866639
DOI: 10.1111/cea.13883

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