Article
GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.
Cell metabolism - 7 Apr 2015
Luzum Jasmine A, Kitzmiller Joseph P, Isackson Paul J, Ma Changxing, Medina Marisa W, Dauki Anees M, Mikulik Eduard B, Ochs-Balcom Heather M, Vladutiu Georgirene D
Abstract excerpt
Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase (GATM rs9806699 G > A) was previously associated with reduced risk for SIM. Our objective was to replicate the GATM association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were...
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