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Article

Mutant Nbs1 enhances cisplatin-induced DNA damage and cytotoxicity in head and neck cancer.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Oct 2004

Tran Hao Mimi, Shi Guoli, Li Gouyan, Carney James P, O'Malley Bert, Li Daqing

Abstract excerpt

OBJECTIVE: Enhanced DNA double-strand break (DSB) repair could be a primary cause for development of resistance in tumor cells to cisplatin, which induces crosslinks and DNA DSBs. A protein complex consisting of hMre11, hRad50, and Nbs1 (MRN) has been identified as a critical component in repair of DNA DSBs. The present study investigates whether the expression of a truncated form of Nbs1 interrupts the function...

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Source

Identifiers

PMID: 15467621
DOI: 10.1016/j.otohns.2004.04.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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