Article
DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN.
Shock (Augusta, Ga.) - 1 Apr 2016
Xu Yongan, Ge Lin, Abdel-Razek Osama, Jain Sumeet, Liu Zhiyong, Hong Yucai, Nieman Gary, Johnson Francis, Golub Lorne M, Cooney Robert N, Wang Guirong
Abstract excerpt
Staphylococcus aureus is a common cause of nosocomial pneumonia frequently resulting in acute respiratory distress syndrome (ARDS). Surfactant protein B (SP-B) gene expresses two proteins involved in lowering surface tension and host defense. Genotyping studies demonstrate a significant association between human SP-B genetic variants and ARDS. Curcumins have been shown to attenuate host inflammation in many...
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