Article
The absolute percent deviation of IGHV mutation rather than a 98% cut-off predicts survival of chronic lymphocytic leukaemia patients treated with fludarabine, cyclophosphamide and rituximab.
British journal of haematology - 1 Jan 2018
Jain Preetesh, Nogueras González Graciela M, Kanagal-Shamanna Rashmi, Rozovski Uri, Sarwari Nawid, Tam Constantine, Wierda William G, Thompson Philip A, Jain Nitin, Luthra Rajyalakshmi, Quesada Andres, Sanchez-Petitto Gabriela, Ferrajoli Alessandra, Burger Jan, Kantarjian Hagop, Cortes Jorge, O'Brien Susan, Keating Michael J, Estrov Zeev
Abstract excerpt
The degree of somatic hypermutation, determined as percent deviation of immunoglobulin heavy chain gene variable region sequence from the germline (IGHV%), is an important prognostic factor in chronic lymphocytic leukaemia (CLL). Currently, a cut-off of 2% deviation or 98% sequence identity to germline in IGHV sequence is routinely used to dichotomize CLL patients into mutated and unmutated groups. Because...
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